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Phytochemical screening and antimicrobial efficacy of
extracts from Khaya senegalensis against human
pathogenic bacteria
D. Kubmarawa1*, M. E. Khan2, A. M.
Punah1 and M. Hassan1
1Department
of Chemistry, Federal University of Technology, P.M.B. 2076,
Yola, Nigeria.
2Department
of Chemistry, Gombe State University, Gombe, Nigeria.
*Corresponding
author. E-mail:
dkubmarawa@yahoo.com.
Accepted 17 July, 2008 |
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Khaya senegalensis
has medicinal properties for the effective management of several ailments
including diarrhea. To establish the pharmacological
rationale for its traditional use, the powdered root,
stem-bark and leaves were extracted with water and ethanol.
All fractions were subjected to phytochemical screening and
antimicrobial activity against gram-positive and
gram-negative bacteria using the disc-diffusion method. The
extracts contained saponins, tannins, phenols but no
flavanoids, glycosides and resin. The stem-bark of the water
fractions and the roots, stem-bark and leaves fractions of
the ethanol fractions were active on Staphylococcus
aureus, Streptococcus spp., Escherichia coli,
Pseudomonas aeruginosa, Salmonella spp. and
Baccilus subtilis,. These findings support the claim for
its treatment of bacterial and fungal infections.
Keywords:
Khaya senegalensis, antimicrobial activity,
Staphylococcus aureus,
Escherichia coli. |
