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Ultrastructure of extensor digitorum longus (EDL) muscle
fibers of alloxan-diabetic rats
Suna Cebesoy*,
Nesrin Özsoy and Nursel Gül
Ankara University, Faculty of Science, Department of
Biology, 06500 Beşevler, Ankara, Turkey.
Corresponding
author. E-mail:
cebesoy@science.ankara.edu.tr. Tel: 00 09 312 2126720/
1128. Fax:00 09 312 2232395.
Accepted 9 April, 2008 |
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The diabetic effects of alloxan (type I diabetes mellitus)
were investigated in 40 Wistar albino rats (18 controls and
22 diabetics). Alloxan in sterile physiological saline was
injected into the animals intravenously. The ultrastructure
of type IIa, type IIb and type I fibers in extensor
digitorum longus (EDL) muscle of normal and alloxan diabetic
rats was studied. In diabetic animals, the mitochondria of
type IIa and type I fibers showed a loss of cristae. There
was also an increased number of lipid droplets. The shape of
the nuclei was highly irregular in these fibers. The type
IIb fibers showed some disorientation of the T-tubuler
system. It is concluded that alloxan-diabetes has
differential effect on the fine structure of the three fiber
types ın rat skeletal muscle.
Key words:
Diabetes mellitus, skeletal muscle, alloxan, ultrastructure. |
