African Journal of Biotechnology Vol. 6 (17), pp. 2023-2027, 5 September 2007   

ISSN 1684–5315 © 2007 Academic Journals        

Full Length Research Paper

Correlation between maternal and cord blood leptin and fetal growth

Rafeey, M^1*, Ouladsahebmadarek, E², Rashtchizadeh, N³, Sheikh Monazah, F⁴, Gorbanihaghjo, A⁵, Hosseini, MB⁶, and Nejati, N⁷.

¹Liver and Gastrointestinal Diseases Research Center -Drug Applied Research Center (DARC), Tabriz University of Medical Sciences, Tabriz, Iran.

²Obstetrics and Gynecology Department, Tabriz University of Medical Sciences, Tabriz, Iran.

³Biochemistry Department, Drug Applied Research Center (DARC) -Biotechnology Research Center, Tabriz, Iran.

⁴General physician, Tabriz University of Medical Sciences, Tabriz, Iran.

⁵Biochemistry Department, Drug Applied Research Center (DARC) -Biotechnology Research Center, Tabriz, Iran.

⁶Neonatology Department, Tabriz University of Medical Sciences, Tabriz, Iran.

⁷Pediatrics Department, Tabriz University of Medical Sciences, Tabriz, Iran.

*Corresponding author. Email:mrafeey@yahoo.com. Fax: 0098-411-5262280. Tel: 0098-9141146982.

Accepted 7 August, 2007

Leptin is a protein secreted mainly by the adipocyte in proportion to fat mass. The serum leptin concentration reflects the amount of adipose tissue in the body and has potential role on the fat deposition in the fetus. In the present study, we investigated whether umbilical and maternal serum leptin concentrations correlate with fetal growth. In addition, we determined the relationship between leptin concentration in the maternal and cord blood. We studied 100 newborn infants (48 female and 52 male; gestational age, 34 - 40 weeks) and their mothers at Alzahra hospital in Tabriz city. Serum leptin concentrations were measured by ELISA and linear regression analysis was used to evaluate correlation. In the results, there was no significant correlation between umbilical and maternal leptin concentrations (r = 0.011; p = 0.459) in all study groups. There was a correlation between umbilical leptin concentration and birth weight of newborns (r = 0.278; p = 0.003) and correlation with body mass index (BMI) of the newborns (r = 0.249; p = 0.006). Maternal leptin concentrations correlated with maternal weight and BMI (r = 0.277; p = 0.003, r = 0.290; p = 0.002, respectively). There was no correlation between maternal leptin concentrations and birth weight (r = - 0.162; p = 0.054) and with BMI of the newborns (r = - 0.158; p = 0.058). There was gender difference in leptin concentrations in the newborns (r = 0.331; p = 0.00025) with greater level in females. In conclusion, we have shown that the association between umbilical serum leptin and birth weight in this and other studies suggests a pivotal role of fetal leptin in regulating fetal growth and development.

Key words: Leptin, Cord blood, Fetal Growth, Maternal.