African Journal of Biotechnology Vol. 6 (3), pp. 247-251, 5 February 2007   

ISSN 1684–5315 © 2007 Academic Journals        

Full Length Research Paper

Long term effects of aqueous stem bark extract of Cissus populnea (Guill. and Per.) on some biochemical parameters in normal rabbits

Ojekale, A. B.¹, Ojiako O. A.²*, Saibu, G. M.¹, Lala, A.¹ and Olodude, O. A.¹

¹Department of Biochemistry, Lagos State University, Ojo, Apapa, Lagos, Nigeria.

²Department of Biochemistry, Federal University of Technology, Owerri, Nigeria.

*Corresponding author. E-mail: okeyojiako@yahoo.com

Accepted 13 November, 2006

In vivo clinical trials involving oral daily administration of crude aqueous extracts of cissus populnea to grouped sprague-dawley rabbits at two dose levels of 200 and 600 gkg^-1 body weight over a 60 day study period revealed that continuous exposure of the plant extract had no damaging effects on the organs of xenobiotic metabolism (liver and kidney). results of levels of serum ast, alt, alkaline phosphatase, creatinine, bilirubin and triglycerides of the two groups were not significantly different (p £ 0.05) at the end of the study from those of the control group.

Key words: Cissus populnea, liver and kidney function, rabbits.