African Journal of Biotechnology Vol. 6 (22), pp. 2515-2518, 19 November 2007   

ISSN 1684–5315 © 2007 Academic Journals        

Full Length Research Paper

Effects of Cucumis metuliferus (Cucurbitaceae) fruits on enzymes and haematological parameters in albino rats

Noel N. Wannang*, Nanloh S. Jimam, Simeon Omale, Maxwell L. P. Dapar, Steven S. Gyang and John C. Aguiyi

Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmaceutical Sciences, University of Jos, Nigeria.

*Correspondence author. E-mail: nnwannang1@yahoo.com. Tel: +234-(0)-803-787-7988.

Accepted 24 October, 2007

The effects of the powdered fruits of Cucumis metuliferus on enzymes and haematological indices were evaluated in adult albino rats. The study revealed a significant (P<0.05) dose-dependent decrease in white blood cells (WBC) count. 500 mg/kg body weight of the powdered fruit produced a significant (P<0.05) decrease in red blood cells (RBC), and an increase in platelet and haemoglobin (Hb), while there was an insignificant (P>0.05) decrease in clotting and bleeding time. 1000 mg/kg produced significant (P<0.05) increase in RBC, platelets, Hb and packed cell volume (PCV) values, and an insignificant (P>0.05) decrease in clotting and bleeding time. The biochemical parameters evaluation showed that 500 - 1000 mg/kg of the powdered fruit of the plant produced a dose-dependent significant (P<0.05) increase in the levels of serum alkaline phosphatase (ALP), aspartate aminotransferase (AST), alanine aminotransferase (ALT), Blood urea nitrogen (BUN) and Total protein. This result showed that Cucumis metuliferus produced alterations in the haematological and biochemical indices evaluated.

Keywords: Cucumis metuliferus, serum, enzymes, haematological