African Journal of Biotechnology Vol. 6 (22), pp. 2628-2632, 19 November 2007   

ISSN 1684–5315 © 2007 Academic Journals        

Full Length Research Paper

Protein modeling of apical membrane antigen-1(AMA-1) of Plasmodium cynomolgi

D.M. Mamatha¹*, K. Nagalakshmamma¹, V.A. Dev Rajesh² and V.S. Sheerin³

¹Department Sericulture and Biosciences Sri Padmavathi women’s University, Tirupati, A.P, India. 517502.

²Department of Bioinformatics, Dravidan University, Kuppam, A.P., India.

³Department of Biosciences Sri Padmavathi women’s University, Tirupati, A.P, India. 517502.

*Corresponding author. E-mail: drdmmamatha@gmail.com.

Accepted 26 October, 2007

Apical membrane Antigen-1(AMA-1), an asexual blood stage antigen of Plasmodium cynomolgi, is an important candidate for testing as a component of malarial vaccine. The degree of conservation of AMA-1 sequences implies a conserved function for this molecule across different species of Plasmodium. Since the AMA-1 of plasmodium cyanomolgi is yet to be structured, the authors have generated a homology model of AMA-1 by using the Swiss-PDB server. The protein’s conservity has been verified by performing multiple alignments using Bioedit and conserved domain database. The model was further checked for its correctness by predicting 2D and 3D structures, which validates the structure.

Key words: Protein model, AMA-1, apical membrane antigen-1, Plasmodium cynomolgi.