African Journal of Biotechnology Vol. 6 (6), pp. 683-684, 19 March 2007   

ISSN 1684–5315 © 2007 Academic Journals        

Short Communication

Usage of U7 snRNA in gene therapy of hemoglobin C disorder: feasibility by gene ontology tool

Viroj Wiwanitkit

Department of Laboratory Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok Thailand 10330. E-mail: wviroj@yahoo.com.

Accepted 29 January, 2007

Hemoglobin (Hb) C disorder is an important hemoglobinopathy with the highest endemicity in Middle East. The red blood cell abnormality is attributed to the beta thalassemic nature of the beta C (b^C) globin gene. Here, a bioinformatic analysis was performed to study the effect of co-expression between human Hb C b-globin chain gene and U7.623. The gene ontological results show that full recovery of hemoglobin function and biological process can be derived. This confirms that U7 snRNA can be a good tool for gene therapy in Hb C disorder.

Key words: hemoglobin C, U7 snRNA.