African Journal of Biotechnology Vol. 6 (12), pp. 1446-1449, 18 June 2007   

ISSN 1684–5315 © 2007 Academic Journals        

Full Length Research Paper

Isolation of antibacterial pentahydroxy flavones from the seeds of Mimusops elengi Linn

K. M. Hazra, R. N. Roy¹, S. K. Sen¹* and S. Laskar

¹Microbiology Division, Department of Botany, School of life Science, Visva-Bharati, Santiniketan – 731 235, India.

Natural Product Laboratory, Department of Chemistry, University of Burdwan, Burdwan – 713 104, India.

*Corresponding author. E-mail: sksenvb@rediffmail.com. Tel- +91-3463-261686, Fax- +91-3463-261268.

Accepted 20 April, 2007

In order to search for antimicrobial phytochemicals, two antibacterial compounds were detected from the seeds of Mimusops elengi Linn. The compounds were extracted by ethyl acetate and purified by column chromatography. Their structures were elucidated through IR, ¹H NMR and GC-EL-MS spectral analyses. After characterization, the compounds were identified as 2,3-dihyro-3,3’4’5,7-pentahydroxyflavone and 3,3’,4’,5,7-pentahydroxyflavone. The compounds showed strong inhibitory activity against Gram positive and Gram negative bacteria.

Key word: Antimicrobial, phytochemical, flavone, seed, Mimusops.