African Journal of Biotechnology Vol. 6 (14), pp. 1681-1684, 18 July 2007   

ISSN 1684–5315 © 2007 Academic Journals        

Full Length Research Paper

Oxidative stress and non-enzymic antioxidant status in hypertensive patients in Nigeria

Nwanjo, H. U.¹*, Oze, G.², Okafor, M. C.², Nwosu, D.¹ and Nwankpa P.²

¹Department of Medical Laboratory Science, Imo State University, Owerri, Imo State.

²Department of Medical Biochemistry, Imo State University, Owerri, Imo State.

*Corresponding author. E-mail: harrisonnwanjo@yahoo.co.uk.

Accepted 11 April, 2007

Oxidative stress and non-enzymic antioxidant status in plasma of hypertensive patients in Nigeria were investigated. One hundred and fifty hypertensive patients (82 males and 68 females) age range 55 – 75 years visiting Federal Medical Centre, Owerri were selected for the study. Controls were 120 apparently healthy subjects (66 males and 54 females) age range 55 -75 years. Patients with complication such as renal diseases, viral and bacterial infections were excluded from the study. In The hypertensive patients presented significantly higher mean values of plasma total cholesterol, LDL-cholesterol and triacyl-glycerols and reduced HDL-cholesterol and phospholipids (p < 0.05). The result of plasma lipid peroxide was significantly higher in hypertensive patients (p < 0.05). Also the levels of non-enzymic antioxidants such as Vitamin C, vitamin E and reduced glutathione in plasma were significantly depleted in the hypertensive patients (p < 0.05). This study shows that hypertension is associated with increased oxidative stress and depleted non-enzymic antioxidant status even in developing countries like Nigeria.

Key words: Oxidative stress, non-enzymic antioxidant and hypertension.