African Journal of Biotechnology
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African Journal of Biotechnology Vol. 5 (17), pp. 1566-1571, 4 September 2006 ISSN 1684–5315 © 2006 Academic Journals
Pharmacological justification for the
ethnomedicinal use of Amblygonocarpus andongensis stem bark in
pain relief
F. C. Nwinyi1*, G. A. Ajoku2,
S. O. Aniagu1, D. Kubmarawa3, N. Enwerem4,
S. Dzarma1 and U.S. Inyang1
1Department
of Pharmacology and Toxicology, National Institute for Pharmaceutical
Research and Development (NIPRD), Idu Industrial Area, P.M.B. 21, Garki,
Abuja, Nigeria.
2Department
of Microbiology, Human Virology and Biotechnology, National Institute
for Pharmaceutical Research and Development (NIPRD), Idu Industrial
Area, P.M.B. 21, Garki, Abuja, Nigeria.
3Department
of Chemistry, Federal University of Technology, P.M.B. 2076, Yola,
Adamawa State, Nigeria.
4Department
of Medicinal Plant Research and Traditional Medicine, National Institute
for Pharmaceutical Research and Development (NIPRD), Idu Industrial
Area, P.M.B. 21, Garki, Abuja, Nigeria.
*Corresponding authors
E-mail:
soa267@bham.ac.uk. Tel:
+234 802 321 5755.
Accepted 6
May, 2006
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| Abstract | |||||
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Amblygonocarpus andongensis (family: Mimosaceae) is ethnomedicinally used in Northern Nigeria for the relief of pain. The methanolic extract of the plant stem bark was evaluated for anti-nociceptive activity using acetic acid-induced writhing model and formalin test in mice. Anti-inflammatory property was tested on egg albumin-induced oedema in rats while agar dilution method was used for antimicrobial effect. The acute toxicity effect (LD50) was also determined via intraperitoneal route. The results showed the LD50 value to be 547.7 mg/kg i.p. There was a significant (P < 0.05) dose-dependent reduction of acetic acid-induced pain at 50, 100, 200 mg/kg i.p. The extract at the same doses significantly (P < 0.05) inhibited pains in both early and late phases of the formalin test. However, the extract showed neither anti-inflammatory nor anti-microbial effects. The results corroborate the folkloric use of the plant.
Key words: Amblygonocarpus andongensis, anti-nociception; anti-inflammation, acute toxicity, antimicrobial effect.
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