African Journal of Biotechnology
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African Journal of Biotechnology Vol. 5 (19), pp. 1781-1784, 2 October 2006 ISSN 1684–5315 © 2006 Academic Journals
Full Length Research Paper
In vitro
study of the interaction between some
fluoroquinolones and extracts of kola nitida seed
IBEZIM, E. C.1, ESIMONE, C. O.1,
NNAMANI, P. O.1, ONYISHI, I. V.2, BROWN, S. A.3
and OBODO, C. E.4
1Department
of Pharmaceutics, University of Nigeria, Nsukka.
2Department
of Pharmaceutical Technology and Industrial Pharmacy, University of
Nigeria, Nsukka.
3Department
of Pharmaceutics and Pharmaceutical Technology, University of
Uyo.
4Department
of Clinical Pharmacy and Pharmacy Management, University of Nigeria,
Nsukka.
Accepted 15 May, 2006 |
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| Abstract | |||||
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The cup diffusion method (CD) was used to evaluate the in vitro interaction of some fluoroquinolones (ciprofloxacin, pefloxacin and levofloxacin) with extracts of Kola nitida seed (KNS) against a clinical isolate of Escherichia coli. Minimum inhibitory concentration (MIC) of the drugs was determined separately and in combination with KNS extract in ratios of 0:5, 1:4, 2:3, 3:2, 4:1 and 5:0 against E. coli. The result of the study revealed that the MIC of the drugs decreased when combined with KNS extract. In other words, KNS extract potentiated the effects of the fluoroquinolones against E. coli.
Key words: Interaction study, ciprofloxacin, pefloxacin, levofloxacin, Kola nitida seed |
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