African Journal of Biotechnology
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African Journal of Biotechnology Vol. 5 (1), pp. 015-020, 2 January 2006 ISSN 1684–5315 © 2006 Academic Journals
Taxol
synthesis B.H. Guo1, G.Y. Kai1, H.B. Jin1 and
K.X. Tang1,2,* 1Plant Biotechnology Research Center,
Fudan-SJTU-Nottingham Plant Biotechnology R&D Center, School of
Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200030,
P. R. China. 2State Key Laboratory of Genetic
Engineering, School of Life Sciences, Fudan-SJTU-Nottingham Plant
Biotechnology R&D Center, Morgan-Tan International Center for Life
Sciences, Fudan University, Shanghai 200433, P. R. China. *Corresponding authors E-mail:
kxtang1@yahoo.com or
kxtang@sjtu.edu.cn;
Accepted 4
October, 2005 |
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| Abstract | |||||
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Being a complex diterpenoid, the potent anticancer drug, Taxol, requires complicated steps for its biosynthesis. In the present article, recent advances on Taxol biosynthesis pathway are reviewed, including many recently reported genes that regulate Taxol biosynthesis. To meet the urgent need of clinic and scientific research, besides Taxus supply, other approaches to obtain Taxol have also been discussed here.
Key words: biosynthesis pathway, cell culture, endophytic fungi, Taxol, Taxus.
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