African Journal of Biotechnology Vol. 5 (8), pp. 668-670, 18 April 2006   

ISSN 1684–5315 © 2006 Academic Journals        

Short Communication

Effects of co-administration of chloroquine with paracetamol or ibuprofen on renal function of rabbits

Okey A. OJIAKO¹* and Harrison U. NWANJO²

¹Department of Biochemistry, Federal University of Technology, Owerri, Nigeria.

²Department of Medical Laboratory Sciences, Imo State University, Owerri, Nigeria.

*Corresponding authors E-mail: okeyojiako@yahoo.com.

Accepted 18 January, 2006

The effects of co-administration of oral chloroquine with paracetamol or with ibuprofen on renal function were studied using 6 groups of New Zealand White rabbits.  Group 1, the control group received only feed and water.  The other groups (Groups 2-6) either received single therapies of paracetamol (10 mg/kg of body weight every 6 hours), ibuprofen (20 mg/kg of body weight/day) or chloroquine (5 mg/kg of body weight/day) or combined therapies of chloroquine and paracetamol or chloroquine and ibuprofen for 8 days.  Measurements of serum urea, creatinine and electrolyte concentrations were used to assess renal function in these animals.  The chloroquine-treated group had a significant (p<0.05) decrease in serum sodium and potassium concentrations and a significant increase (p<0.05) in serum urea and creatinine concentrations when compared with the corresponding values of the control group.  The groups treated with combined therapy (groups 5 and 6) had significant increases (P<0.05) in serum urea and creatinine concentrations, and significant decreases in sodium and potassium levels when compared with the chloroquine-treated group (group 4).  These results confirm that acute administration of chloroquine impairs kidney function and further shows that this renotoxicity is exacerbated when chloroquine is co-administered with paracetamol or with ibuprofen, two common drugs used to manage fever.

Key words: Chloroquine, co-administration, paracetamol, ibuprofen renal toxicity.