Short Communication

In vivo activities of Baicalin against Chlamydia trachomatis

Qi Xiaojuan^1,2, Fu lei¹, Su Wen¹,Yi Yandong¹ and Huang Hao¹*

¹Center of Experimental Medicine, Wuhan First Hospital, Wuhan City 430022, P.R. China.

²Maternal and Child Care Service Centre in Wuhan's Qingshan District, Wuhan City 430022, P.R. China.

*Corresponding author. E-mail: whhuanghao10@yahoo.com.cn. Tel: +86 27 85332365.

Abbreviations: HIV, Human immunodeficiency virus; HPLC, high performance liquid chromatography.

Accepted 19 January, 2010

   Abstract

Our previous studies have shown that Baicalin could effectively inhibit Chlamydia trachomatis in vitro. In this study, Baicalin was tested for potential antichlamydial activity using a murine genital Chlamydia trachomatis infection model. It was demonstrated that Baicalin significantly reduced C. trachomatis loading in BALB/c mice that were vaginally infected with the pathogen. On the basis of these data and our previous observations, we concluded that further evaluation of Baicalin for prevention and treatment of sexually transmitted chlamydial infection is warranted.

Key words: Chlamydia trachomatis, Baicalin, vaginally infected.